BeOne Medicines

BeOne Medicines Ltd. (BeOne), formerly BeiGene, is a global oncology company. Its main medicine is BRUKINSA (zanubrutinib), a BTK inhibitor for blood cancers such as chronic lymphocytic leukemia, with global sales of $1.4 billion in Q3 2026. It also sells TEVIMBRA (tislelizumab), a PD-1 antibody, and BEQALZI (sonrotoclax), a BCL2 inhibitor that the U.S. FDA approved in May 2026 for relapsed or refractory mantle cell lymphoma.

In China it also sells medicines licensed from Amgen. Total revenue was $1.89 billion in Q3 2026. BeOne has nearly 12,000 employees and its own manufacturing in China and the United States. It is incorporated in Switzerland, with its registered office in Basel.

Its American depositary shares (ADS) trade on Nasdaq as ONC, and each ADS represents 13 ordinary shares. The shares also trade in Hong Kong and Shanghai. John V. Oyler is Co-Founder, Chairman and Chief Executive Officer.

The market prices BeOne mainly on BRUKINSA, which gave about three quarters of product revenue in Q3 2026. Investors doubt how long BRUKINSA can keep its fast growth against other BTK medicines, and whether the large research budget will produce the next medicines before the main BRUKINSA patent ends in 2034. Its links to China add policy risk. For the shares to earn more, three things must be true.

BRUKINSA must keep gaining share in chronic lymphocytic leukemia and add first-line mantle cell lymphoma, where the FDA gave the MANGROVE filing priority review. BEQALZI and the BTK degrader tacabrutideg must move towards wider approvals. And the operating margin must keep rising as revenue grows. The MANGROVE results at ASH in December 2026 and the Q4 2026 report with the 2027 guidance, expected in February 2027, are the next tests.

1. Nov 5, 2026Passed

   Q3 2026 results: BRUKINSA growthBRUKINSA growth of 25% or more and a higher operating margin pass; slower growth fails.Outcome: BRUKINSA sales rose 34%, and BeOne raised its 2026 revenue and operating income guidance.
2. Dec 2026 · est.Pending

   ASH 2026: MANGROVE results in first-line mantle cell lymphomaA clear progression-free survival benefit for BRUKINSA in the plenary session passes; a weak or unclear benefit fails.
3. Feb 5, 2027 · est.Pending

   Q4 2026 results and 2027 guidance2027 guidance with revenue growth of 15% or more and a higher operating margin passes; lower growth fails.

Every passed and failed checkpoint across all picks

• November 5, 2026BeOne reported Q3 2026 results. Total revenue rose 34% to $1.89 billion, and BRUKINSA sales rose 34% to $1.4 billion. GAAP diluted EPS was $3.28 per ADS and non-GAAP diluted EPS was $4.59 per ADS. BeOne raised its 2026 guidance to revenue of $6.9 billion to $7.0 billion and non-GAAP operating income of $1.9 billion to $2.0 billion. It also reported FDA priority review for the MANGROVE filing of BRUKINSA in first-line mantle cell lymphoma.
• August 5, 2026BeOne reported Q2 2026 results. Total revenue rose 30% to $1.7 billion, and BeOne raised its 2026 revenue guidance to $6.6 billion to $6.8 billion.
• June 26, 2026BeOne said that it settled a statutory tax audit in China. It agreed to pay income tax, surcharges and interest of about RMB 446 million, with no penalty.

Last earnings

November 5, 2026 (8-K on sec.gov)

Next earnings

Expected about February 5, 2027. The company has not confirmed the date.

• 10-QQuarterly report for the period ended Sep 30, 2026Filed November 5, 2026 · bgne-20260930
• 8-KEarnings releaseFiled November 5, 2026 · Press release and exhibits
• 8-KEarnings releaseFiled August 26, 2026 · Press release and exhibits
• 10-QQuarterly report for the period ended Jun 30, 2026Filed August 5, 2026 · bgne-20260630
• 8-KEarnings releaseFiled August 5, 2026 · Press release and exhibits
• 8-KOther company newsFiled June 26, 2026 · bgne-20260626
• 8-KChange of directors or officers and Shareholder vote resultsFiled June 11, 2026 · bgne-20260611
• 8-KOther company newsFiled May 15, 2026 · bgne-20260513
• 10-QQuarterly report for the period ended Mar 31, 2026Filed May 6, 2026 · bgne-20260331
• 8-KEarnings releaseFiled May 6, 2026 · Press release and exhibits

Every filing on SEC EDGAR (CIK 1651308)

• BRUKINSA gave about three quarters of product revenue in Q3 2026. Stronger competition from other BTK inhibitors or new treatments for chronic lymphocytic leukemia would lower growth fast.
• Generic companies can challenge the BRUKINSA patents. Zydus challenged some Orange Book patents in 2026. The composition of matter patent runs until 2034 in the United States.
• U.S. drug pricing policy, such as the executive orders of 2025 on most-favored-nation prices and Medicare price negotiation, can lower prices in the largest market.
• In China, the government sets reimbursement and uses volume-based procurement, which lowers prices. Tax audits, such as the 2026 settlement of about RMB 446 million, and tension between the United States and China add risk.
• BeOne spends about $2.4 billion a year on research and development. Failed trials of medicines such as BEQALZI or tacabrutideg would lower future growth.
• Share-based compensation was $393 million in the first nine months of 2026. New share awards dilute the holders.

BeOne has much more cash than debt. At September 30, 2026, cash and cash equivalents were $5,781 million, and restricted cash was $85 million. Read more

BeOne Medicines does not pay a dividend.

Source: company filings and market data, read on November 10, 2026.